863234-27-9

Upstream product

• 4630-82-4 methyl cyclohexylcarboxylate 
• 678988-77-7 methyl 1-(prop-2-yn-1-yl)cyclohexane-1-carboxylate 

Downstream Products

• 863234-28-0 toluene-4-sulfonic acid 1-prop-2-ynyl-cyclohexylmethyl ester 
• 1093663-22-9 tert-butyldimethyl((1-(prop-2-ynyl)cyclohexyl)methoxy)silane 
• 1176666-91-3 (1-((4,5-dihydro-4-methylpyrrolo[1,2-a]quinoxalin-4-yl)methyl)cyclohexyl)methanol 
• 1224955-03-6 12b-methyl-3,12b-dihydro-1'H-spiro[cyclohexane-1,2-dipyrrolo[1,2-a:2,1-c]quinoxaline] 
• 1344031-56-6 4-(3-methyl-2-oxaspiro[4.5]decan-3-yl)-4-phenyl-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one 
• 1344031-57-7 (S)-4-((R)-3-methyl-2-oxaspiro[4.5]decan-3-yl)-4-phenyl-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one 
• 1344031-65-7 (S)-4-(4-bromophenyl)-4-((R)-3-methyl-2-oxaspiro[4.5]decan-3-yl)-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one 
• 1344031-64-6 (R)-4-(4-bromophenyl)-4-((R)-3-methyl-2-oxaspiro[4.5]decan-3-yl)-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one 
• 1344031-77-1 (S)-4-(4-methoxyphenyl)-4-((R)-3-methyl-2-oxaspiro[4.5]decan-3-yl)-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one 
• 1344031-76-0 (R)-4-(4-methoxyphenyl)-4-((R)-3-methyl-2-oxaspiro[4.5]decan-3-yl)-2-(3,4,5-trimethoxyphenyl)oxazol-5(4H)-one 
• 1427302-92-8 (3S,5R)-3-(perfluorophenylamino)-1,14-dioxadispiro[4.1.5.2]tetradecan-2-one 
• 1427302-93-9 (3S,5S)-3-(perfluorophenylamino)-1,14-dioxadispiro[4.1.5.2]tetradecan-2-one 
• 1427302-94-0 (3S,5R)-3-(3-bromophenylamino)-1,14-dioxadispiro[4.1.5.2]tetradecan-2-one 

Relevant academic research and scientific papers

PtCl2-Catalyzed Cycloisomerization of 1,8-Enynes: Synthesis of Tetrahydropyridine Species

The cycloisomerization of 1,8-enynes in the presence of platinum(II) chloride was developed to generate bicyclic nitrogen-containing heterocycle species via 6-endo-dig cyclization and [3,3]-sigmatropic rearrangement in acceptable to good yields. The relat

Synthesis of Sultones from Chlorosulfates by a Complex Cascade Reaction Occurring under Mild Thermal Conditions

Chlorosulfate derivatives are interesting reagents that have been traditionally used to get other sulfur-containing compounds by formal nucleophilic substitution of the chlorine atom. This work describes a different mode of reactivity of alkyne-containing

Synthesis of 6-Substituted Piperidin-3-ones via Rh(II)-Catalyzed Transannulation of N-Sulfonyl-1,2,3-triazoles with Electron-Rich Aromatic Nucleophiles

A highly diastereoselective rhodium(II)-catalyzed transannulation of aldehyde-tethered N-sulfonyl triazoles with electron-rich aromatic nucleophiles is reported for the first time to afford functionalized 6-substituted piperidin-3-ones. The reaction has a broad substrate scope including both aliphatic and aromatic N-sulfonyl-1,2,3-triazoles together with various aromatic nucleophiles. The addition of a catalytic amount of Lewis acid has proven to be crucial for the yield improvement. By employing this methodology, hardly accessible piperidin-3-ones bearing quaternary carbons could be obtained.

Chemoselective amination of propargylic C(sp3)-H bonds by cobalt(II)-based metalloradical catalysis

Highly chemoselective intramolecular amination of propargylic C(sp 3)-H bonds has been demonstrated for N-bishomopropargylic sulfamoyl azides through cobalt(II)-based metalloradical catalysis. Supported by D 2h-symmetric amidoporphyrin ligand 3,5-DitBu-IbuPhyrin, the cobalt(II)-catalyzed C-H amination proceeds effectively under neutral and nonoxidative conditions without the need of any additives, and generates N 2 as the only byproduct. The metalloradical amination is suitable for both secondary and tertiary propargylic C-H substrates with an unusually high degree of functional-group tolerance, thus providing a direct method for high-yielding synthesis of functionalized propargylamine derivatives. Make a ring of it: Highly chemoselective intramolecular amination of propargylic C(sp3)-H bonds has been achieved with a high degree of functional-group tolerance through the title reaction. The [Co(P1)]-catalyzed C-H amination proceeds under neutral and nonoxidative conditions without the need of any additives, thus providing a direct method for efficient synthesis of functionalized propargylamine derivatives with N2 as the only by-product.

A silver-promoted auto-tandem catalysis for the synthesis of multiply substituted tetrahydrocarbazoles

Silver(i) triflate efficiently catalyzes the tandem reaction of acetylenic aldehydes with indoles to give highly substituted tetrahydrocarbazoles in high yields.

Synthesis and characterization of β-haloalkenyl-λ3- bromanes: Stereoselective markovnikov addition of difluoro(aryl)- λ3-bromane to terminal acetylenes

Reported here for the first time are the synthesis, isolation, and characterization of hypervalent β-haloalkenyl-λ3-bromanes. Exposure of terminal alkynes to p-trifluoromethylphenyl(difluoro)-λ3-bromane activated by BF3-i-Pr2O resulted in fluoro-λ3-bromanation of the triple bonds in a Markovnikov fashion, yielding (E)-β-fluoroalkenyl-λ3-bromanes stereoselectively in good yields. 5-Chloro-1-pentynes undergo domino λ3-bromanation-chlorine shift-fluorination or λ3-bromanation-chlorine shift-alkyl shift-fluorination reaction, depending on the substituents and afford (E)-β-chloroalkenyl-λ3-bromanes stereoselectively in high yields. The β-chloroalkenyl-λ3-bromanes contain three kinds of halogen atoms, F, Cl, and Br, in the molecule. Copyright