863237-55-2Relevant academic research and scientific papers
Enantio selective synthesis of new phenylpropanoid: Isolated from Walsura trifoliata
Ramana,Suri Appa Rao,Apparao,Nageswara Rao
, p. 2042 - 2046 (2019/08/08)
A new phenylpropanoid containing flavon-3-ol has been isolated from the leaves of traditional medicinal plant, Walsura trifoliata. The structure of the compound was established on the basis of spectroscopic evidence [2D NMR, HREIMS] and by its alternative
Improved synthesis of structural analogues of (-)-epicatechin gallate for modulation of staphylococcal β-lactam resistance
Anderson, James C.,Grounds, Helen,Reeves, Suzanna,Taylor, Peter W.
, p. 3485 - 3490 (2014/05/06)
The high-yielding synthesis of enantiomerically pure epicatechin gallate analogues where the A and/or B-ring hydroxylation is reduced or altered has been achieved by optimising routes to the catechin stereochemistry. The B-ring analogues were synthesised by using an electrophilic ring closure onto an enantiomerically enriched epoxide as a key step. The A and B-ring hydroxyl-deleted analogues were synthesised through a Mitsunobu cyclisation. For the B-ring analogues, the anti- (catechin) stereochemistry was converted to the syn- (epicatechin) stereochemistry by a known oxidation/reduction protocol. Absolute stereochemistry was derived from either a Sharpless epoxidation or asymmetric dihydroxylation.
Asymmetric total synthesis of B-ring modified (-)-epicatechin gallate analogues and their modulation of β-lactam resistance in Staphylococcus aureus
Anderson, James C.,Headley, Catherine,Stapleton, Paul D.,Taylor, Peter W.
, p. 7703 - 7711 (2007/10/03)
Two enantiomerically pure B-ring modified analogues of (-)-epicatechin gallate were synthesised and their modulation of β-lactam resistance using three strains of methicillin resistant Staphylococcus aureus (BB 568, EMRSA-15 and EMRSA-16) evaluated. Sub-i
