863238-73-7

Basic information

• Product Name: 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole
• Synonyms: 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole;4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1-(triphenylMethyl)-1H-pyrazole;1-Trityl-1H-pyrazole-4-boronic acid pinacol ester
• CAS NO: 863238-73-7
• Molecular Formula: C₂₈H₂₉BN₂O₂
• Molecular Weight: 436.36
• Mol File: 863238-73-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 587.3 °C at 760 mmHg
• Flash Point: 309 °C
• Appearance: /
• Density: 1.07±0.1 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.37±0.10(Predicted)
• CAS DataBase Reference: 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole(863238-73-7)
• EPA Substance Registry System: 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole(863238-73-7)

Safety Data

• Hazardous Substances Data: 863238-73-7(Hazardous Substances Data)

Usage

General Description

4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole is a complex synthesized chemical compound the structure of which is composed of a 1H-pyrazole core substituted with a trityl group and a tetramethyl-[1,3,2]dioxaborolan-2-yl group. The trityl group is a triphenylmethyl derivative which is utilized in the protection of functional groups in organic synthesis, while the tetramethyl-[1,3,2]dioxaborolan-2-yl group is a boronic ester commonly used in cross-coupling reactions like Suzuki coupling. However, the specific application, physiological and environmental effects of 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1-trityl-1H-pyrazole are not largely documented, suggesting that they may be primarily used within specific scientific or industrial contexts. It is necessary for those handling such chemicals to be aware of any potential hazards and to take appropriate safety precautions.

InChI:InChI=1/C28H29BN2O2/c1-26(2)27(3,4)33-29(32-26)25-20-30-31(21-25)28(22-14-8-5-9-15-22,23-16-10-6-11-17-23)24-18-12-7-13-19-24/h5-21H,1-4H3

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 76-83-5 trityl chloride 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 5419-55-6 Triisopropyl borate 
• 95162-14-4 4-bromo-1-trityl-1H-pyrazole 

Downstream Products

• 1874148-75-0 1,3,5-tri(1-trityl-1H-pyrazol-4-yl)benzene 
• 226989-36-2 4-hydroxy-1-trityl-1H-pyrazole 

Relevant articles and documents

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2

NVS-SM2, the first activator of pre-mRNA splicing, displays remarkable pharmacological in vivo activities in models of spinal muscular atrophy. Herein we describe an improved approach to the synthesis of this compound, which features a convenient introduction of sterically encumbered amine moiety onto a fluoropyridazine intermediate.

Efficient and chromatography-free methodology for the modular synthesis of oligo-(1H-pyrazol-4-yl)-arenes with controllable size, shape and steric bulk

A novel methodology to synthesise oligo-(1H-pyrazol-4-yl)-arenes with controllable size, shape and steric bulk from 1-trityl-1H-pyrazol-4-ylboronate pinacol esters. This straightforward and efficient procedure can be applied to a variety of brominated aro