863296-73-5Relevant academic research and scientific papers
Compounds and compositions as lxr modulators
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Page/Page column 8, (2010/01/31)
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
N-acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRβ
Molteni, Valentina,Li, Xiaolin,Nabakka, Juliet,Liang, Fang,Wityak, John,Koder, Alan,Vargas, Leo,Romeo, Russell,Mitro, Nico,Mak, Puiying A.,Seidel, H. Martin,Haslam, Jennifer A.,Chow, Donald,Tuntland, Tove,Spalding, Tracy A.,Brock, Ansgar,Bradley, Michelle,Castrillo, Antonio,Tontonoz, Peter,Saez, Enrique
, p. 4255 - 4259 (2008/02/13)
We have identified a novel liver X receptor (LXR) agonist (2) that activates the LXRβ subtype with selectivity over LXRα. LXRβ selectivity was confirmed using macrophages derived from LXR mutant mice. Despite its selectivity and modest potency, the compou
