863296-76-8Relevant academic research and scientific papers
Total Syntheses of Rhodomolleins XX and XXII: A Reductive Epoxide-Opening/Beckwith–Dowd Approach
Yu, Kuan,Yang, Zhen-Ning,Liu, Chun-Hui,Wu, Shao-Qi,Hong, Xin,Zhao, Xiao-Li,Ding, Hanfeng
, p. 8556 - 8560 (2019)
A new TiIII-mediated reductive epoxide-opening/ Beckwith–Dowd rearrangement process efficiently assembles the bicyclo[3.2.1]octane framework of highly oxidized grayanane diterpenoids. By incorporation of a Cu(tbs)2-catalyzed (tbs=N-tert-butylsalicylaldiminato) intramolecular cyclopropanation, a diastereoselective oxidative dearomatization-induced Diels–Alder cycloaddition and a MeReO3-catalyzed Rubottom oxidation, this approach has enabled the first total syntheses of rhodomolleins XX and XXII in 23 and 22 steps, respectively.
Compounds and compositions as lxr modulators
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Page/Page column 9, (2010/01/31)
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).
Rapid construction of the cortistatin pentacyclic core
Simmons, Eric M.,Hardin, Alison R.,Guo, Xuelei,Sarpong, Richmond
supporting information; experimental part, p. 6650 - 6653 (2009/03/12)
(Chemical Equation Presented) Ringing in cortistatin: The pentacyclic core of the cortistatin steroidal alkaloids has been readily assembled in eleven steps from simple building blocks (see scheme; PMB=para-methoxybenzyl, TBS=tert-butyldimethylsilyl). An
