863303-83-7

Upstream product

• 444344-91-6 4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylic acid 

Downstream Products

• 863303-82-6 4-aminobicyclo[2.2.2]octane-1-carboxamide 
• 1252672-88-0 benzyl (4-cyanobicyclo[2.2.2]oct-1-yl)carbamate 

Relevant academic research and scientific papers

NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF

The present invention relates to inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

BICYCLIC AMIDE DERIVATIVES

Novel bicycloamide derivatives (general formula (1)) and pharmaceutically acceptable salts thereof effectively inhibit DPP-IV. The bicycloamide derivatives are represented by the general formula (1): Pharmaceutically acceptable salts thereof are also included (Example: (2S,4S)-1-[[(4-carbamoylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile)).