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86334-95-4

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86334-95-4 Usage

General Description

1-[(carboxymethyl)(nitroso)amino]-1-deoxyhex-2-ulopyranose, also known as nitroso glucaric acid, is a molecule with a complex structure. It contains a hexose sugar backbone with a carboxymethyl group, a nitroso group, and an amino group attached to it. The presence of these functional groups gives it unique chemical properties and potential applications in various fields such as pharmaceuticals, food additives, and industrial processes. Nitroso glucaric acid may have antioxidant, antitumor, and antimicrobial properties, making it a potential candidate for drug development and food preservation. Its specific structure and properties make it an interesting molecule for further research and potential practical uses.

Check Digit Verification of cas no

The CAS Registry Mumber 86334-95-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,3,3 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 86334-95:
(7*8)+(6*6)+(5*3)+(4*3)+(3*4)+(2*9)+(1*5)=154
154 % 10 = 4
So 86334-95-4 is a valid CAS Registry Number.

86334-95-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[nitroso-[(2,3,4,5-tetrahydroxyoxan-2-yl)methyl]amino]acetic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86334-95-4 SDS

86334-95-4Upstream product

86334-95-4Downstream Products

86334-95-4Relevant articles and documents

In the search for new anticancer drugs. XXV: Role of N-nitrosated Amadori compounds derived from glucose-amino acid conjugates in cancer promotion or inhibition

Sosnovsky,Gnewuch,Ryoo

, p. 649 - 656 (2007/10/02)

Earlier investigators found that some N-nitrosated Amadori compounds, derived from glucose and amino acid condensation reactions, exhibit mutagenic properties and theorized that these potentially carcinogenic compounds might be formed in the human digestive system. To further investigate these compounds, N-nitrosated Amadori compounds [i.e., N-(1-deoxy-D-fructos-1-yl)- L-N-nitroso-glycine (5a), -threonine (5b), -methionine (5c), -valine (5d), - phenylalanine (5e), and -tryptophan (5f)] were synthesized by modifications of known methods. Acute toxicity tests of 5a, 5b, 5c, 5d, 5e, and 5f in male Swiss mice produced the following lowest lethal limits of toxicity: 2000, 2000, 4000, 3000, 2000, and 6000 mg/kg, respectively, whereas the highest tolerated doses were 1750, 1500, 3000, 1500, and 5000 mg/kg, respectively. The 50% lethal dose (intraperitoneally) for 5b in mice was ~1777 mg/kg. This value is at least three times higher than that for the over-the-counter drug Ibuprofen (i.e., 495 mg/kg, intraperitoneally, in mice). Compounds 5b, 5c, 5d, and 5f were evaluated in vitro by the National Cancer Institute primary antitumor screen consisting of 60 cell lines. None of the four compounds caused a significant inhibition of cell growth, even at the maximum dosage of 10-4 M. Compounds 5a-f were tested in vivo against the lymphocytic leukemia P388, and 5b and 5f were tested against the lymphoid leukemia L1210 in CDF1 male mice following the National Cancer Institute protocol. There were no significant differences in results between the control and drug-treated mice. The percent increase in lifespan ranged from -15 to +15 (T/C = 85-115) for P388 and from -5 to +1 (T/C = 95-101) for L1210, whereas the values for the positive control 5-fluorouracil were 71 and 67 (T/C = 171 and 167), respectively. The combination of very low acute toxicity, low in vitro cytotoxicity in primary tumor screens, and no activity in vivo led to the hypothesis that none of the compounds 5a-f are carcinogenic or cytotoxic. It is possible that these compounds are not metabolically activated by either α- or β-oxidations or by retro-aldol cleavage reactions.

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