863399-92-2Relevant academic research and scientific papers
Novel antifungal agents: Triazolopyridines as inhibitors of β-1,6-glucan synthesis
Kuroyanagi, Jun-Ichi,Kanai, Kazuo,Sugimoto, Yuuichi,Fujisawa, Tetsunori,Morita, Chikanori,Suzuki, Takashi,Kawakami, Katsuhiro,Takemura, Makoto
, p. 5845 - 5854 (2010)
Preparations and in vitro antifungal activities of triazolopyridines, imidazopyridines, and a pyrazolopyridine were reported. Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of β-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species.
