863407-40-3Relevant articles and documents
Conformationally restricted homotryptamines. 2. Indole cyclopropylmethylamines as selective serotonin reuptake inhibitors
Mattson, Ronald J.,Catt, John D.,Denhart, Derek J.,Deskus, Jeffrey A.,Ditta, Jonathan L.,Higgins, Mendi A.,Marcin, Lawrence R.,Sloan, Charles P.,Beno, Brett R.,Gao, Qi,Cunningham, Melissa A.,Mattson, Gail K.,Molski, Thaddeus F.,Taber, Matthew T.,Lodge, Nicholas J.
, p. 6023 - 6034 (2007/10/03)
A series of indole cyclopropylmethylamines were found to be potent serotonin reuptake inhibitors. Nitrile substituents at the 5 and 7 positions of the indole ring gave high affinity for hSERT, and the preferred cyclopropane stereochemistry was determined