863442-90-4Relevant academic research and scientific papers
HIV INTEGRASE INHIBITORS
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, (2015/09/22)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
Synthesis and antiviral activity of 7-benzyl-4-hydroxy-1,5-naphthyridin- 2(1H)-one HIV integrase inhibitors
Boros, Eric E.,Edwards, Cynthia E.,Foster, Scott A.,Fuji, Masahiro,Fujiwara, Tamio,Garvey, Edward P.,Golden, Pamela L.,Hazen, Richard J.,Jeffrey, Jerry L.,Johns, Brian A.,Kawasuji, Takashi,Kiyama, Ryuichi,Koble, Cecilia S.,Kurose, Noriyuki,Miller, Wayne H.,Mote, Angela L.,Murai, Hitoshi,Sato, Akihiko,Thompson, James B.,Woodward, Mark C.,Yoshinaga, Tomokazu
experimental part, p. 2754 - 2761 (2010/01/16)
The medicinal chemistry and structure-activity relationships for a novel series of 7-benzyl-4-hydroxy-1,5-naphthyridin-2(1H)-one HIV-integrase inhibitors are disclosed. Substituent effects were evaluated at the N-1, C-3, and 7-benzyl positions of the naph
A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate
Boros, Eric E.,Burova, Svetlana A.,Erickson, Greg A.,Johns, Brian A.,Koble, Cecilia S.,Kurose, Noriyuki,Sharp, Matthew J.,Tabet, Elie A.,Thompson, James B.,Toczko, Matthew A.
, p. 899 - 902 (2012/12/30)
A scaleable synthesis of methyl 3-amino-5-(4-fluorobenzyl)-2- pyridinecarboxylate (1b), starting from 5-bromo-2-methoxypyridine (8) and 4-fluorobenzaldehyde (9), is described. Key steps in the process include lithium-bromine exchange of 8, addition of the
