863453-50-3

Upstream product

• 863453-34-3 (E)-3-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-methyl-acrylic acid methyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 189996-60-9 2,3-O-isopropylidene-D-erythrose 
• 25581-41-3 D-erythronolactone acetonide 

Downstream Products

• 863453-39-8 (E)-(2S,3S)-2-Benzyloxy-3-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-4,8-dimethyl-non-4-enoic acid methyl ester 
• 863453-38-7 Benzyloxy-acetic acid (S)-1-{(E)-2-[(4S,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-methyl-vinyl}-4-methyl-pentyl ester 
• 863453-40-1 (E)-(2S,3S)-2-Benzyloxy-3-[(4S,5R)-2,2-dimethyl-5-(toluene-4-sulfonyloxymethyl)-[1,3]dioxolan-4-yl]-4,8-dimethyl-non-4-enoic acid methyl ester 
• 863453-37-6 (E)-(S)-1-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2,6-dimethyl-hept-1-en-3-ol 
• 863453-52-5 (E)-(R)-1-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2,6-dimethyl-hept-1-en-3-ol 
• 863453-53-6 (E)-(2S,3S)-2-Benzyloxy-3-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-4,8-dimethyl-non-4-enoic acid methyl ester 
• 863453-35-4 (E)-3-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-propenal 
• 863453-51-4 (E)-3-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-2-methyl-prop-2-en-1-ol 

Relevant academic research and scientific papers

Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol

Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated. The cyclopentane-fumagillol derivatives were synthesized from (-)-2,3-O- isopropylidene-d-erythronolactone via stereoselective glycolate Claisen rearrangement and intramolecular ester enolate alkylation as key steps.