863479-34-9

Upstream product

• 97315-18-9 p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 558-13-4 carbon tetrabromide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 621-59-0 isovanillin 
• 388566-83-4 1-(3-tert-butyldimethylsilyloxy-4-methoxyphenyl)-2,2-dibromoethene 

Downstream Products

• 871940-23-7 1-ethynyl-3-hydroxy-4-methoxybenzene 
• 831222-67-4 5-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)isoxazole 
• 863479-40-7 (E)-2-(3-hydroxy-4-methoxyphenyl)vinylboronic acid 
• 863479-44-1 (1Z,3E)-1-(3',4',5'-trimethoxyphenyl)-4-(3''-hydroxy-4''-methoxyphenyl)-1,3-butadiene 
• 1034293-31-6 5-(3-(tert-butyldimethylsilyloxy)-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole 
• 1352957-65-3 C₂₂H₂₈O₄Si 
• 1363603-20-6 5-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-2-methoxyphenol 
• 1380079-55-9 C₂₂H₂₇Br₂N₃O₃Si 
• 1363603-22-8 5-(1-(3,5-diiodo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-2-methoxyphenol 
• 1034292-85-7 C₁₈H₁₉N₃O₅ 
• 831222-65-2 tert-butyl-(2-methoxy-5-vinylphenoxy)dimethylsilane 

Relevant academic research and scientific papers

Conjugation of Hydroxytyrosol with Other Natural Phenolic Fragments: From Waste to Antioxidants and Antitumour Compounds

Hydroxytyrosol, a natural polyphenol that can be extracted from olive mill waste waters, was converted into a series of more complex and lipophilic analogues by conjugation with other naturally derived (poly)phenolic fragments. Ether and triazole linkers were employed. A small library of compounds was prepared, stressing step economy and operational simplicity. Some of these substances were proven to have activity equal or superior to that of the parent hydroxytyrosol in radical scavenging assays as well as in cytotoxicity tests against tumour cells.

Amidobenzothiazoles And Process For The Preparation Thereof

The present invention provides a compound of general formulae A useful as potential anti-cancer agents against human cancer cell lines and a process for the preparation thereof. Where in R, R1, R2═H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G= Where in R, R1, R2═H, alkyl, alkoxy, halo, haloalkyl, halomethoxy, nitro and G=

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1

The antiproliferative activity on ovarian cancer (SK-OV-3) cells of a series of triazole-bridged combretastatin analogues (37, 38, 40-43) containing dihalogenation of the A-ring is reported, and compared with their trimethoxy analogues (5, 15, 39). It was found that dihalogenation with either bromine or iodine was a tolerated modification when compared to the parent compound combretastatin (CA-4, 1) and had less effect than B-ring modification on potency. These compounds exhibited G2/M arrest, and maintained antitubulin activity. Further assays on human umbilical vein endothelial cells (HUVECs) demonstrated the potential antivascular effects of these triazoles. Of particular note was a 3,5-diiodo-4-methoxyaryl triazole (43) which had promising 7-fold selectivity for HUVECs over ovarian cancer cells.

1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents

A series of cis-restricted 1,4- and 1,5-disubstituted 1,2,3-triazole analogs of combretastatin A-4 (1) have been prepared. Cytotoxicity and tubulin inhibition studies showed that 2-methoxy-5-((5-(3,4,5-trimethoxyphenyl)-1H-1,2, 3-triazol-1-yl)methyl)aniline (5e) and 2-methoxy-5-(1-(3,4,5-trimethoxybenzyl)- 1H-1,2,3-triazol-5-yl)aniline (6e) were two of the most active compounds. Molecular modeling studies revealed that the N-2 and N-3 atoms in the triazole rings in 5e and 6e did not form hydrogen bonds with the amino acids in the anticipated pharmacophore.

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

A series of cis-restricted 1,5-disubstituted 1,2,3-triazole analogues of combretastatin A-4 (1) have been prepared. The triazole 12f, 2-methoxy-5-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)aniline, displayed potent cytotoxic activity against severa

Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives

Stereospecific syntheses of the Z-E and E-Z vinylogues of combretastatin A-4, and two B-ring related analogues, were achieved through a Suzuki-Miyaura coupling. As compared to CA4, the derivative with a phenyl moiety has shown increased potency in its abi