863480-39-1Relevant academic research and scientific papers
Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors
Clemente,Domingos,Grancho,Iley,Moreira,Neres,Palma,Santana,Valente
, p. 1065 - 1068 (2001)
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the β-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and f
Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted β-lactams as novel inhibitors of human leukocyte elastase
Moreira, Rui,Santana, Ana Bela,Iley, Jim,Neres, Jo?o,Douglas, Kenneth T.,Horton, Peter N.,Hursthouse, Michael B.
, p. 4861 - 4870 (2007/10/03)
Human leukocyte elastase (HLE) is a serine protease that very efficiently degrades various tissue matrix proteins such as elastin. The imbalance between HLE and its endogenous inhibitors leads to excessive elastin proteolysis and is considered to be respo
