863491-46-7

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 55309-58-5 pyridine-2,6-dicarboximidic acid dimethyl ester 
• 5431-44-7 2,6-Pyridinedicarboxaldehyde 
• 626-05-1 2,6-Dibromopyridine 
• 119072-55-8 tert-butylisonitrile 

Downstream Products

• 874304-95-7 (4R,5R)-2-[6-((4R,5R)-4,5-Diphenyl-4,5-dihydro-1H-imidazol-2-yl)-pyridin-2-yl]-4,5-diphenyl-4,5-dihydro-imidazole-1-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 
• 863491-57-0 2,6-bis-(1-[toluene-4-sulfonyl]-[4R,5R]-4,5-diphenyl-4,5-dihydro-1H-imidazol-2-yl)-pyridine 

Relevant academic research and scientific papers

Palladium-catalyzed multicomponent synthesis of 2-aryl-2-imidazolines from aryl halides and diamines

An efficient palladium-catalyzed three-component reaction that combines aryl halides, isocyanides, and diamines provides access to 2-aryl-2-imidazolines in yields up to 96%. Through variation of the diamine component, the reaction can be extended to the s

Facile preparation of 2-imidazolines from aldehydes with tert-butyl hypochlorite

An efficient and high-yield preparation of 2-imidazolines was achieved from aldehydes and ethylenediamines in the presence of tert-butyl hypochlorite. By this method, 1,3-bis(imidazolin-2-yl)benzene and 2,6-bis(imidazolin-2-yl) pyridine, which act as chiral ligands, could be prepared directly from the corresponding dialdehydes in high yields. Georg Thieme Verlag Stuttgart.

Synthesis of a new chiral N,N,N-tridentate pyridinebisimidazoline ligand library and its application in Ru-catalyzed asymmetric epoxidation

(Chemical Equation Presented) A small ligand library of chiral tridentate N,N,N-pyridinebisimidazolines have been synthesized for the first time. This new class of ligands can be easily tuned and synthesized on multi g-scale. The usefulness of the ligands is shown in the ruthenium-catalyzed asymmetric epoxidation with hydrogen peroxide as oxidant. Excellent yields (>99%) and good enantioselectivities (up to 71% ee) have been obtained for the epoxidation of aromatic olefins.

Synthesis of a novel class of chiral N,N,N-tridentate pyridinebisimidazoline ligands and their application in Ru-catalyzed asymmetric epoxidations

A new class of easily tunable N,N,N-pyridinebisimidazoline (pybim) ligands have been synthesized. The synthesis and tunability of these chiral tridentate ligands are much easier and flexible compared to the popular pyboxes, making the former a suitable ligand tool box for various asymmetric transformations. Ruthenium complexes of the new ligands were synthesized and applied in the asymmetric epoxidation of olefins using hydrogen peroxide as the oxidant. Excellent yields and moderate to good enantioselectivities were achieved in the epoxidation of aromatic olefins.