863503-01-9Relevant academic research and scientific papers
Syntheses and biological activities of daunorubicin analogs with uncommon sugars
Zhu, Lizhi,Cao, Xianhua,Chen, Wenlan,Zhang, Guisheng,Sun, Duxin,Wang, Peng George
, p. 6381 - 6387 (2005)
To study the effects of the sugar structure on the activity of anthracycline against cancer cells, six daunorubicin analogs containing different uncommon sugars were synthesized. Their cytotoxicities were tested against colon cancer cells by MTS assay. Th
Syntheses and biological activities of 3′-azido disaccharide analogues of daunorubicin against drug-resistant leukemia
Zhang, Guisheng,Fang, Lanyan,Zhu, Lizhi,Zhong, Yanqiang,Wang, Peng George,Sun, Duxin
, p. 1792 - 1799 (2007/10/03)
Anthracyclines, such as daunorubicin (DNR) and doxorubicin (Dox), are widely used for cancer therapy but are limited by drug resistance and cardiotoxicity. To overcome drug resistance, we synthesized a novel class of disaccharide analogues of DNR against
MULTIDRUG RESISTANT ANTICANCER ANTHRACYCLINES
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Page/Page column 13; 22-23, (2008/06/13)
Daunorubicin ("DNR") compounds synthesized with uncommon sugars exhibit enhanced effectiveness in treating various drug-resistant cancers.
