863514-54-9

Upstream product

• 1002916-54-2 [8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride 

Downstream Products

• 1189796-35-7 4-(dimethylamino)-4-(3-fluorophenyl)-1-(3-methyl-1H-indol-2-yl)cyclohexanol 
• 1189796-34-6 4-(dimethylamino)-4-(3-fluorophenyl)-1-(3-methyl-1H-indol-2-yl)cyclohexanol 
• 1189555-37-0 4-dimethylamino-4-(3-fluorophenyl)-cyclohexane carbaldehyde 
• 1189555-03-0 1-(4-(dimethylamino)-4-(3-fluorophenyl)cyclohexyl)-2-phenylethanol 
• 1357001-60-5 AMN-2trans 
• 1357001-59-2 AMN-2cis 
• 1357001-61-6 cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine 
• 1357001-74-1 cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine 
• 1357001-83-2 trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(3,4-dimethoxy-benzyl)carbonyl-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine 
• 1357001-79-6 AMD-3trans 
• 1357001-77-4 cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-benzylcarbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine 
• 1357001-80-9 trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(benzothiophen-2-yl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate (1:1) 
• 1357001-75-2 cis-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-(3-fluorophenyl)-2'-(benzyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine 
• 1357001-72-9 AMD-6cis 

Relevant academic research and scientific papers

Cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine Compounds

Cis-tetrahydro-spiro(cyclohexane-1,1′-pyrido[3,4-b]indole)-4-amine compounds which act on the nociceptin/ORL-1 receptor system as well as on the μ-opioid receptor system and which are distinguished in particular by selective effectiveness in the treatment of chronic pain, such as inflammatory pain, visceral pain, tumour pain, and neuropathic pain, without at the same time developing pronounced effectiveness against acute, nociceptive pain.

Substituted Spiroamine Compounds

Substituted spiroamine compounds corresponding to the formula (I) In which m, n, o, p, Q, r, s, t, R1, R2, R3, R4a, R4b, R5a, R5b, R6a, R6b, R7, R8, R9, R10 and R11 have defined meanings; a process for the preparation of such compounds, pharmaceutical compositions containing such compounds and the use of substituted spiroamines for the treatment or inhibition of pain and/or other conditions mediated by the bradykinin 1 receptor.

Spirocyclic Azaindole Derivatives

The invention relates to substituted azaindole derivatives, to methods for the production thereof, to medicaments containing said compounds and to the use of substituted azaindole derivatives for producing medicaments.