863604-93-7Relevant academic research and scientific papers
Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties
Mader, Mary,de Dios, Alfonso,Shih, Chuan,Bonjouklian, Rosanne,Li, Tiechao,White, Wesley,de Uralde, Beatriz Lopez,Sanchez-Martinez, Concepcion,del Prado, Miriam,Jaramillo, Carlos,de Diego, Eugenio,Martin Cabrejas, Luisa M.,Dominguez, Carmen,Montero, Carlos,Shepherd, Timothy,Dally, Robert,Toth, John E.,Chatterjee, Arindam,Pleite, Sehila,Blanco-Urgoiti, Jaime,Perez, Leticia,Barberis, Mario,Lorite, Maria Jose,Jambrina, Enrique,Nevill Jr., C. Richard,Lee, Paul A.,Schultz, Richard C.,Wolos, Jeffrey A.,Li, Li C.,Campbell, Robert M.,Anderson, Bryan D.
, p. 179 - 183 (2008/09/18)
Herein we report investigations into the p38α MAP kinase activity of trisubstituted imidazoles that led to the identification of compounds possessing highly potent in vivo activity. The SAR of a novel series of imidazopyridines is demonstrated as well, resulting in compounds possessing cellular potency and enhanced in vivo activity in the rat collagen-induced arthritis model of chronic inflammation.
KINASE INHIBITORS
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Page/Page column 26, (2010/02/13)
ABSTRACT The present invention provides kinase inhibitors of Formula I: .
