863640-77-1

Upstream product

• 13154-24-0 triisopropylsilyl chloride 
• 18282-51-4 4-iodo-benzyl alcohol 

Downstream Products

• 863640-78-2 1-triisopropylsilanyloxymethyl-4-trimethylsilanylethynyl-benzene 
• 1253955-24-6 3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionic acid 
• 1253955-23-5 3-[(tert-butoxycarbonyl)amino]-2-[4-[[(triisopropylsilyl)oxy]methyl]phenyl]propionate 
• 1253955-22-4 ethyl 3-amino-2-(4-(((triisopropylsilyl)oxy)methyl)phenyl)propionate 
• 1253955-21-3 ethyl 2-cyano-2-(4-((triisopropylsilyloxy)methyl)phenyl)acetate 
• 851227-35-5 (4-{3-isopropyl-4-methoxymethoxy-5-[4-(triisopropylsilanyloxymethyl)phenylethynyl]benzyl}-3,5-dimethylphenoxy)acetic acid methyl ester 
• 851227-54-8 {4-[3-(4-azidomethylphenylethynyl)-5-isopropyl-4-methoxymethoxybenzyl]-3,5-dimethylphenoxy}acetic acid methyl ester 
• 863640-99-7 {4-[3-(4-hydroxymethyl-phenylethynyl)-5-isopropyl-4-methoxymethoxy-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 863641-31-0 {4-[3-(4-azidomethyl-phenylethynyl)-4-hydroxy-5-isopropyl-benzyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester 
• 851227-22-0 (4-ethynylbenzyloxy)triisopropylsilane 

Relevant academic research and scientific papers

Hammett analysis of selective thyroid hormone receptor modulators reveals structural and electronic requirements for hormone antagonists

Selective thyroid hormone modulators that function as isoform-selective agonists or antagonists of the thyroid hormone receptors (TRs) might be therapeutically useful in diseases associated with aberrant hormone signaling. The most potent thyroid hormone

COMPOUNDS FOR THE TREATMENT OF OCULAR DISEASE

Disclosed herein are compounds for the treatment of ocular diseases and the preparation and use thereof. Some implementations relate to amine and sulfonamide derivatives and their use as therapeutic agents for the treatment of glaucoma.

Preparation method of netarsudil key intermediate

The invention provides a preparation method of a netarsudil key intermediate, and the netarsudil key intermediate is prepared from a halogenated benzyl alcohol as a starting material in turn by benzyl alcohol group protection, malonate catalyzed coupling, aminolysis, reduction, amino protection and hydrolysis. The raw materials are cheap and easy to obtain, the reaction conditions are mild, the reaction controllability is high, and the method has good industrial application prospect.

DUAL-ACTION INHIBITORS AND METHODS OF USING SAME

Provided are compounds, compositions, and methods for treating diseases and conditions wherein an inhibitor of a kinase, such as rho kinase (ROCK), and an inhibitor of one or more of the monoamine transporters, such as NET or SERT, act in concert to improve the condition.