863650-75-3Relevant academic research and scientific papers
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
Bond, Andrew D.,Hanby, Abigail R.,King, Thomas A.,Moss, Thomas A.,Sore, Hannah F.,Spring, David R.,Stewart, Hannah L.
supporting information, p. 6818 - 6821 (2020/07/04)
Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.
Transformation of amino acids into nonracemic 1-(heteroaryl)ethanamines by the enamino ketone methodology
Pirc, Samo,Bevk, David,Golobic, Amalija,Stanovnik, Branko,Svete, Jurij
, p. 30 - 44 (2007/10/03)
N-Protected L-phenylalanines 1a,b were transformed, via the corresponding Weinreb amides 2 and ethynyl ketones 3, into chiral enamino ketones 4 (Scheme 1). Similarly, L-threonine 6 was transformed in four steps into the enamino ketone 10. Cyclocondensatio
Synthesis of functionalized compounds containing pyridazine and related moieties
Svete, Jurij
, p. 361 - 373 (2007/10/03)
3-Aminopyridazines 17 and 3-hydrazinopyridazines 18 were used as building blocks for the preparation of various types of functionalized, pyridazine ring containing compounds. 3-Aminopyridazines were employed in the synthesis of 3-(6-chloroimidazo[1,2-b]py
