863659-66-9Relevant academic research and scientific papers
Androsterone 3α-ether-3β-substituted and androsterone 3β-substituted derivatives as inhibitors of type 3 17β-hydroxysteroid dehydrogenase: Chemical synthesis and structure - Activity relationship
Ngatcha, Béatrice Tchédam,Luu-The, Van,Labrie, Fernand,Poirier, Donald
, p. 5257 - 5268 (2007/10/03)
Type 3 17β-hydroxysteroid dehydrogenase (17β-HSD) is involved in the biosynthesis of androgen testosterone. To produce potent inhibitors of this key steroidogenic enzyme, we prepared a series of androsterone (ADT) derivatives by adding a variety of substi
