863663-22-3

Upstream product

• 863663-16-5 (1R)-1-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]ethanone 
• 809272-98-8 (1R)-1-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]ethanol 
• 863663-31-4 1-O-[tert-butyl(dimethyl)silyl]-2,4,7,8-tetradeoxy-9-O-(4-methoxybenzyl)-2,4,8-trimethyl-6-C-methyl-6-O-(triethylsilyl)-L-glycero-D-gulo-non-3-ulose 
• 863663-20-1 (4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-5-{(1R,3R)-4-[(4-methoxybenzyl)oxy]-1,3-dimethyl-1-[(trethylsilyl)oxy]butyl}-4-methyl-4,5-dihydroisoxazole 
• 863663-18-7 (2R,4R)-2-[(4S,5R)-3-((1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-methylethyl)-4-methyl-4,5-dihydroisoxazol-5-yl]-5-[(4-methoxybenzyl)oxy]-4-methylpentan-2-ol 
• 863663-32-5 9-O-[tert-butyl(dimethyl)silyl]-2,3,6,8-tetradeoxy-1-O-(4-methoxybenzyl)-2,6,8-trimethyl-4-C-methyl-4-O-(triethylsilyl)-L-threo-L-ido-nonitol 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 863663-33-6 3,5-O-benzylidene-1-O-[tert-butyl(dimethyl)silyl]-2,4,7,8-tetradeoxy-2,4,8-trimethyl-6-C-methyl-6-O-(triethylsilyl)-L-threo-L-ido-nonitol 

Relevant academic research and scientific papers

Stereoselective synthesis of erythronolide A via nitrile oxide cycloadditions and related studies

(Chemical Equation Presented) An expeditious synthesis of erythronolide A is documented. Key steps of the approach include two magnesium-mediated nitrile oxide cycloadditions, a chelation-controlled Grignard reaction, and a Sharpless asymmetric dihydroxylation. 2009 American Chemical Society.

Total synthesis of erythronolide A by MgII-mediated cycloadditions of nitrile oxides

(Chemical Equation Presented) A cycloaddition comes of age: The focal points of a stereoselective total synthesis of erythronolide A (see structure) are two MgII-mediated cycloadditions of nitrile oxides. Of broader significance, the strategy not only facilitates the synthesis of specific polyketide targets (i.e. natural products) but also opens up new possibilities for the preparation of non-natural analogues.