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Usage

Uses

Used in Pharmaceutical Research:
6-(3-Chlorophenyl)-picolinic acid is used as a ligand in metal coordination complexes for the development of pharmaceutical agents. Its unique structure allows for the formation of stable complexes with metal ions, which can be utilized in the design of new drugs with improved properties.
Used in Agrochemical Research:
In the agrochemical industry, 6-(3-Chlorophenyl)-picolinic acid is used as a bioactive compound for the development of pesticides and other agrochemicals. Its ability to exhibit bioactivity against certain pests and diseases makes it a promising candidate for the creation of more effective and targeted agrochemical products.
The precise applications and potential effects of 6-(3-Chlorophenyl)-picolinic acid are the subject of ongoing research and development within the scientific community, as its full potential in various fields is yet to be fully explored and understood.

Upstream product

• 63503-60-6 3-chlorophenylboronic acid 
• 122918-25-6 6-bromopyridin-2-carbonitrile 
• 21190-87-4 6-bromo-pyridine-2-carboxylic acid 

Downstream Products

• 1415894-42-6 Methyl 2-(6-(3-chlorophenyl)picolinamido)-2-methylpropanoate 

Relevant academic research and scientific papers

Structure-Activity Relationship for the Picolinamide Antibacterials that Selectively Target Clostridioides difficile

Clostridioides difficile is a leading health threat. This pathogen initiates intestinal infections during gut microbiota dysbiosis caused by oral administration of antibiotics. C. difficile is difficult to eradicate due to its ability to form spores, which are not susceptible to antibiotics. To address the urgent need for treating recurrent C. difficile infection, antibiotics that selectively target C. difficile over common gut microbiota are needed. We herein describe the class of picolinamide antibacterials which show potent and selective activity against C. difficile. The structure-activity relationship of 108 analogues of isonicotinamide 4, a compound that is equally active against methicillin-resistant Staphylococcus aureus and C. difficile, was investigated. Introduction of the picolinamide core as exemplified by analogue 87 resulted in exquisite potency and selectivity against C. difficile. The ability of the picolinamide class to selectively target C. difficile and to prevent gut dysbiosis holds promise for the treatment of recurrent C. difficile infection.

A chiral picolinic acid ligand, Cl-NAPH-PyCOOH, for CPRU-catalyzed dehydrative allylation: Design, synthesis, and properties

A CpRu/Br?nsted acid-combined catalyst, CpRu(II)/pico-linic acid (PyCOOH), acts as an efficient catalyst for the allyl protection/deprotection of alcohols. This discovery has resulted in the development of a new axially chiral ligand, Cl-Naph-PyCOOH (2a;

EP2 RECEPTOR AGONISTS

A compound of Formula (I) or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of Formulae (Ai), (Aii), (Aiii) D is selected from Formulae (Di), (Dii), (Diii), (Div), (Dv) B is selected from the group consisting of Formulae (Bi), (Bii), (Biii), (Biv) (Bv).