863715-19-9

Basic information

• Product Name: N-α-Fmoc-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester
• Synonyms: N-α-Fmoc-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester
• CAS NO: 863715-19-9
• Molecular Weight: 714.858
• Mol File: 863715-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-α-Fmoc-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-α-Fmoc-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester(863715-19-9)
• EPA Substance Registry System: N-α-Fmoc-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester(863715-19-9)

Safety Data

• Hazardous Substances Data: 863715-19-9(Hazardous Substances Data)

Upstream product

• 172611-73-3 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol 
• 118488-18-9 Fmoc-D-Tyr(O-tBu)-OH 
• 863715-16-6 N-α-Fmoc-O-tert-butyl-D-tyrosine 4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl ester 

Relevant articles and documents

On-resin cyclization of a head-to-tail cyclopeptide using an allyldimethylsilyl polystyrene resin pre-loaded by metathesis

Here, we report the solid-phase synthesis of a 17-mer cyclopeptide which is expected to have anti-angiogenic properties. The peptidic synthesis is performed on an allyldimethylsilyl polystyrene support loaded by metathesis with a conveniently functionalized D-Tyrosine amino acid. The linear peptide was assembled by standard Fmoc chemistry and on-resin cyclization was enabled after selective deprotection of the C-terminal group with 2% hydrazine/DMF at room temperature. Final cleavage was realized under mild acidic conditions allowing to obtain a cyclopeptide under partially protected form.