863753-73-5Relevant academic research and scientific papers
CDP PROTEIN SECRETION INHIBITORS
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Paragraph 0122-0123, (2019/10/19)
rovided herein are compounds that inhibit protein secretion, e.g., via inhibition of Sec61. Also provided are compositions of the inhibitor compounds, and methods of using these inhibitors. The compounds disclosed herein can be used, e.g., for the treatme
Solid-phase synthesis of a cyclodepsipeptide: Cotransin
Coin, Irene,Beerbaum, Monika,Schmieder, Peter,Bienert, Michael,Beyermann, Michael
supporting information; experimental part, p. 3857 - 3860 (2009/07/09)
(Chemical Equation Presented) The first solid-phase synthesis of cotransin-a cyclic depsipeptide having high pharmacological potential-was achieved, by a proper choice of coupling reagents and use of either TBAF or DBU for Fmoc removal to suppress the otherwise dominating, sequence-derived diketopiperazine formation. Starting the assembly from C-terminal lactic acid allowed fast and epimerization-free cyclization in solution. Novel conditions for orthogonal use of the Fmoc/Bsmoc-protection system were discovered, and an unexpected nucleophilic behavior of DBU was observed.
