863867-97-4Relevant academic research and scientific papers
Silylcuprates from allene and their reaction with α,β- unsaturatedd nitriles and imines. Synthesis of silylated oxo compounds leading to cyclopentane and cycloheptane ring formation
Barbero, Asuncion,Blanco, Yolanda,Pulido, Francisco J.
, p. 6876 - 6883 (2005)
The silylcupration of allenes and the subsequent capture of the intermediate cuprate with α,β-unsaturated nitriles is reported. The influence of the substitution of the nitrile, the nature of the silylcopper species, and the temperature on the selectivity
Efficiency of acid- and mercury-catalyzed cyclization reactions in the synthesis of tetrahydrofurans from allylsilyl alcohols
Pulido, Francisco J.,Barbero, Asuncion,Val, Patricia,Diez, Alberto,Gonzalez-Ortega, Alfonso
, p. 5350 - 5356 (2012/10/29)
The scope of the acid-catalyzed and mercury-catalyzed cyclization reactions of allylsilyl alcohols is described. This methodology has been found to be an efficient approach to the synthesis of highly substituted tetrahydrofurans. The stereoselectivity of the cyclization is dependent both on the substitution of the starting alcohol and on the catalyst. A plausible mechanism has been proposed that is consistent with the results. Copyright
