863868-23-9Relevant academic research and scientific papers
NOVEL 2-AMINO-5,5-DIARYL-IMIDAZOL-4-ONES
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Page/Page column 69-70, (2008/12/06)
This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Di
NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES
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Page/Page column 166-167, (2008/12/06)
This invention relates to novel compounds having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
Process for producing cyano substituted arene boranes and compounds
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Page/Page column 13, (2008/06/13)
A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.
Sterically directed functionalization of aromatic C-H bonds: Selective borylation ortho to cyano groups in arenes and heterocycles
Chotana, Ghayoor A.,Rak, Michael A.,Smith, Milton R.
, p. 10539 - 10544 (2007/10/03)
Ir-catalyzed borylations of 4-substituted benzonitriles are described. In contrast to electrophilic aromatic substitutions and directed ortho metalations, C-H activation/borylation enables functionalization at the 2-position, adjacent to the cyano group, when the 4-subsitutent is larger than cyano. When an excess of borane reagent is used, diborylation can be achieved with a single regioisomer being formed in certain cases. Extension of sterically directed borylation to cyano-substituted, five- and six-membered ring heterocycles is also reported.
