863868-94-4

Upstream product

• 863868-89-7 1-[(E)-3-(4-fluorophenyl)acryloyl]pyrrolidin-2-one 
• 109-77-3 malononitrile 
• 116422-24-3 1-<(Diethoxyphosphinyl)acetyl>-2-pyrrolidinone 
• 1237797-49-7 C₁₃H₁₂FNO₂ 
• 711028-98-7 1-(2-bromoacetyl)pyrrolidin-2-one 

Downstream Products

• 609341-24-4 (3S)-4,4,-dicyano-3-(4-fluorophenyl)butanoic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis, and application of chiral electron-poor guanidines as hydrogen-bonding catalysts for the Michael reaction

The first chiral electron-poor guanidine organocatalysts were synthesized. The presence of a tunable electron-withdrawing group on the guanidine moiety allows for the modulation of the catalysts' activity. The application of this new class of organocatalysts to the Michael reaction is demonstrated.

Enantioselective Michael addition to α,β-unsaturated imides catalyzed by a bifunctional organocatalyst

(Chemical Equation Presented) High enantioselectivities (up to 94 % ee) were attained in the Michael addition of a variety of α,β-unsaturated imides 1 and malononitrile (2) catalyzed by bifunctional thiourea 4. The pyrrolidinone moiety of 1 plays a key ro