863886-29-7Relevant academic research and scientific papers
Development of antiproliferative phenylmaleimides that activate the unfolded protein response
Muus, Ulrike,Hose, Curtis,Yao, Wei,Kosakowska-Cholody, Teresa,Farnsworth, David,Dyba, Marzena,Lountos, George T.,Waugh, David S.,Monks, Anne,Burke Jr., Terrence R.,Michejda, Christopher J.
supporting information; experimental part, p. 4535 - 4541 (2010/08/22)
The current paper presents the synthesis and evaluation of a series of maleimides that were designed to inhibit the Cdc25 phosphatase by alkylation of catalytically essential cysteine residues. Although in HepB3 cell culture assays the analogues did exhib
