86390-73-0

Upstream product

• 6780-38-7 N-phthaloylglycine chloride 
• 88852-09-9 (R,E)-1-(2,4-dimethoxyphenyl)-N-((2,2-dimethyl-1,3-dioxolan-4-yl)methylene)methanamine 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 56710-46-4 L-5,6-isopropylidene-gulono-1,4-lactone 
• 1089691-24-6 phthaloylglycine acid chloride 
• 7487-88-9 magnesium sulfate 

Downstream Products

• 86334-58-9 (3S,4S)-3-amino-1-(2,4-dimethoxybenzyl)-4-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)azetidin-2-one 
• 86299-41-4 (3S,4S)-3-(benzyloxycarboxamido)-1-(2,4-dimethoxybenzyl)-4-formyl-2-azetidinone 
• 86334-59-0 benzyl ((2S,3S)-1-(2,4-dimethoxybenzyl)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-oxoazetidin-3-yl)-carbamate 

Relevant academic research and scientific papers

Process Development for the Synthesis of a Monobactam Antibiotic-LYS228

A scalable process for the novel monobactam antibiotic LYS228 has been developed. This paper covers a novel scalable process for producing β-lactam 10 in the multiple kilogram scale. An alternative approach to compound 7 without protecting-group exchange

SALTS AND SOLID FORMS OF MONOBACTAM ANTIBIOTIC

Providing new solid forms, salts and polymorphs of 1-(((Z)-(1-(2-aminothiazol-4-yl) -2-oxo-2-(((3S,4R)-2-oxo-4-((2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3-yl) amino)ethylidene)amino)oxy)-cyclopropanecarboxylic acid (referred to herein as compound X), pharmaceutical compositions containing them, and processes for their manufacture and use in therapy.

MONOBACTAM ORGANIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS

This invention pertains generally to antibacterial compounds of Formula I, as further described herein, and pharmaceutically acceptable salts and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds to treat infections such as those caused by Gram-negative bacteria.

Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage

The manufacture of 1-sulpho-2-oxazetidine derivatives of the formula STR1 in which Het is an optionally amino-substituted, 5- or 6-membered, aromatic heterocycle containing 1 or 2 nitrogen atoms and optionally also an oxygen or sulphur atom, R1

A Convenient Synthesis of L-(S)-Glyceraldehyde Acetonide from L-Ascorbic Acid

L-(S)-glyceraldehyde acetonide is easily obtained from L-ascorbic acid by three-step procedure.Since the aldehyde is rather unstable in pure form it is more convenient to use it as an aqueous solution.It was used to synthesize L-(R)-glycerol acetonide, monocyclic-β-lactams, and olefins (by Wittig reaction).

Method of producing (S)-glyceraldehyde acetonide

A method of producing (S)-glyceraldehyde acetonide, which comprises reacting 3,4-O-isopropylidene-L-threonic acid or a salt thereof with hypochlorite ion or hypochlorous acid under an acid condition. Also a method of producing (S)-glyceraldehyde acetonide, which comprises reacting 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof with an oxidizing agent to produce 3,4-O-isopropylidene-L-threonic acid or a salt thereof and then reacting the 3,4-O-isopropylidene-L-threonic acid or a salt thereof with hypochlorite ion or hypochlorous acid under an acid condition. Also a method for producing (S)-glyceraldehyde acetonide, which comprises (1) reacting L-ascorbic acid or a salt thereof with acetone or a conventional equivalent thereof to produce 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof; (2) reacting the 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof with an oxidizing agent to produce 3,4-O-isopropylidene-L-threonic acid or a salt thereof; and (3) reacting the 3,4-O-isopropylidene-L-threonic acid or a salt thereof with hypochlorite ion or hypochlorous acid under an acid condition.