863905-89-9

Upstream product

• 35092-89-8 4-(methoxycarbonyl)-3-nitrobenzoic acid 
• 863905-58-2 3-(2-methoxy-2-oxoethoxy)-2-(methoxycarbonyl)benzo[b]thiophene-6-carboxylic acid 
• 863905-52-6 6-tert-butyl 2-methyl 3-hydroxybenzo[b]thiophene-2,6-dicarboxylate 
• 881033-90-5 methyl 6-(chlorocarbonyl)-3-(2-methoxy-2-oxoethoxy)benzo[b]thiophene-2-carboxylate 
• 85485-59-2 5-methyl-1-phenyl-1H-pyrazol-3-amine 
• 147291-52-9 tert-butyl 4-(methoxycarbonyl)-3-nitrobenzoate 
• 863905-54-8 6-tert-butyl 2-methyl 3-(2-methoxy-2-oxoethoxy)benzo[b]thiophene-2,6-dicarboxylate 

Relevant academic research and scientific papers

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors

A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallo

Inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.