863920-71-2Relevant academic research and scientific papers
Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists
Guo, Zhiqiang,Tellew, John E.,Gross, Raymond S.,Dyck, Brian,Grey, Jonathan,Haddach, Mustapha,Kiankarimi, Mehrak,Lanier, Marion,Li, Bin-Feng,Luo, Zhiyong,McCarthy, James R.,Moorjani, Manisha,Saunders, John,Sullivan, Robert,Zhang, Xiaohu,Zamani-Kord, Said,Grigoriadis, Dimitri E.,Crowe, Paul D.,Chen, Ta Kung,Williams, John P.
, p. 5104 - 5107 (2007/10/03)
The synthesis and SAR studies of tricyclic imidazo[4,5-b]pyridin-2-ones as human corticotropin-releasing factor receptor (CRF1) antagonists are discussed herein. Compound 16g was identified as a functional antagonist that inhibited CRF-stimulat
