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86393-32-0

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86393-32-0 Usage

Chemical Properties

Pale yellow, crystalline, slightly hygroscopic powder.

Uses

Different sources of media describe the Uses of 86393-32-0 differently. You can refer to the following data:
1. Ciprofloxacin hydrochloride has been suggested as a treatment for a wide range of infections caused by susceptible organisms including infections of urinary, respiratory, and gastrointestinal tracts, gonorrhoea and septicaemia. Nalidixic acid analogue.
2. Fluoroquinolone antibacterial.

Application

Ciprofloxacin hydrochloride hydrate is a broad-spectrum antibiotic that inhibits bacterial DNA gyrase and blocks DNA synthesis and replication, resulting in bacterial death. It has strong antibacterial activity against Escherichia coli, Klebsiella and other Enterobacteriaceae; the antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae is better than norfloxacin and pefloxacin.

Definition

ChEBI: The monohydrate form of ciprofloxacin monohydrochloride.

Brand name

Ciloxan (Alcon); Cipro (Bayer); Proquin (Esprit).

General Description

Ciprofloxacin HCl is a fluoroquinolone antibiotic agent, which shows a broad spectrum of antibacterial activity against gram positive and gram negative bacteria.

in vitro

Ciprofloxacin (hydrochloride monohydrate) is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity. Ciprofloxacin (hydrochloride monohydrate) (CIP) shows potent activity against Y. pestis with MIC 90 of 0.03 μg/mL.

in vivo

Ciprofloxacin (hydrochloride monohydrate) (1 mg/L) induces glutathione-S-transferase (GST) activity, in contrast with inhibited GST and Catalase (CAT) of larvae exposed to enrofloxacin. Ciprofloxacin (hydrochloride monohydrate) (≥10 μg/L) is ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae. In a murine model of pneumonic plague, Ciprofloxacin (hydrochloride monohydrate) (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in human following a 500 mg dose of oral Ciprofloxacin (hydrochloride monohydrate). Intraperitoneal Ciprofloxacin (hydrochloride monohydrate) reduces the lung bacterial load compare to controls treated with intraperitoneal PBS.

Check Digit Verification of cas no

The CAS Registry Mumber 86393-32-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,3,9 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 86393-32:
(7*8)+(6*6)+(5*3)+(4*9)+(3*3)+(2*3)+(1*2)=160
160 % 10 = 0
So 86393-32-0 is a valid CAS Registry Number.
InChI:InChI=1/C17H18FN3O3.ClH.H2O/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;;/h7-10,19H,1-6H2,(H,23,24);1H;1H2

86393-32-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (C2227)  Ciprofloxacin Hydrochloride Monohydrate  >98.0%(HPLC)(T)

  • 86393-32-0

  • 5g

  • 220.00CNY

  • Detail
  • TCI America

  • (C2227)  Ciprofloxacin Hydrochloride Monohydrate  >98.0%(HPLC)(T)

  • 86393-32-0

  • 25g

  • 690.00CNY

  • Detail
  • TCI America

  • (C2227)  Ciprofloxacin Hydrochloride Monohydrate  >98.0%(HPLC)(T)

  • 86393-32-0

  • 100g

  • 1,790.00CNY

  • Detail

86393-32-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name ciprofloxacin hydrochloride hydrate

1.2 Other means of identification

Product number -
Other names 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,hydrate,hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86393-32-0 SDS

86393-32-0Synthetic route

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate
86393-32-0

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate

ciprofloxacin hydrochloride
93107-08-5

ciprofloxacin hydrochloride

Conditions
ConditionsYield
In ethanol for 24 - 72h; Product distribution / selectivity;88%
In iso-butanol for 2h; Product distribution / selectivity;88%
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate
86393-32-0

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate

europium(III) chloride hexahydrate

europium(III) chloride hexahydrate

water
7732-18-5

water

[Eu(ciprofloxacin)(ciprofloxacin(-1H))(H2O)4]Cl2*8H2O

[Eu(ciprofloxacin)(ciprofloxacin(-1H))(H2O)4]Cl2*8H2O

Conditions
ConditionsYield
With 1,3-bis(dimethylamino)-2-propanol In ethanol; water High Pressure; Eu salt, ligand and 1,3-bis(dimethylamino)-2-propanol added to a mixt. of H2O and EtOH, stirred, placed in an autoclave, heated at 150°C for 48 h; crystd. for 1 wk; elem. anal.;47.2%
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate
86393-32-0

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate

water
7732-18-5

water

mercury dichloride

mercury dichloride

(H-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid)2HgCl4*2H2O

(H-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid)2HgCl4*2H2O

Conditions
ConditionsYield
In water satd. aq. solns. ligand and HgCl2 were mixed in 2:1 ratio; ppt. was filtered off, dried in air; elem. anal.;
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate
86393-32-0

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate

aqueous cadmium chloride

aqueous cadmium chloride

(H-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carbohylic acid)2(CdCl4)*2H2O

(H-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carbohylic acid)2(CdCl4)*2H2O

Conditions
ConditionsYield
In water satd. aq. solns. ligand and CdCl2*2.5H2O were mixed in 2:1 ratio; ppt. was filtered off, dried in air; elem. anal.;
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate
86393-32-0

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate

aqueous cadmium chloride

aqueous cadmium chloride

(H2-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid)CdCl4*H2O

(H2-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid)CdCl4*H2O

Conditions
ConditionsYield
With HCl In hydrogenchloride solns. ligand and CdCl2*2.5H2O in concd. HCl were mixed in 1:1 ratio, mixt. was stand for several days; ppt. was filtered off, washed with acetone, dried in air; elem. anal.;
1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate
86393-32-0

1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid HCl monohydrate

mercury dichloride

mercury dichloride

(H2-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid)HgCl4

(H2-1-cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydroquinoline-3-carboxylic acid)HgCl4

Conditions
ConditionsYield
With HCl In hydrogenchloride solns. ligand and HgCl2 in concd. HCl were mixed in 1:1 ratio, mixt. wasstand for several days; ppt. was filtered off, washed with acetone, dried in air; elem. anal.;

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