86396-69-2

Usage

Molecular Weight

230.26 g/mol

Chemical Group

Dioxolane derivatives

Structure

A dioxolane ring with a 4-methoxyphenyl group at position 3 and a phenyl group at position 5, in a trans configuration

Applications

a. Pharmaceutical industry
b. Research industry

Biological and Pharmacological Activities

a. Inhibits the proliferation of cancer cells
b. Potential use in the development of anticancer drugs
c. Possible applications in the treatment of other diseases and conditions

Unique Properties

a. Chemical structure that contributes to its potential biological and pharmacological activities
b. Trans configuration of the 4-methoxyphenyl and phenyl groups, which may influence its interactions with biological targets

Upstream product

• 34221-26-6 trans-1-(4-methoxyphenyl)-2-phenylcyclopropane 
• 670-54-2 ethenetetracarbonitrile 
• 53400-00-3 1-methoxy-4-((1RS,2SR)-2-phenylcyclopropyl)benzene 

Relevant academic research and scientific papers

[3+2] Photooxygenation of aryl cyclopropanes via visible light photocatalysis

We report that Ru(bpz)32+ is an excellent sensitizer for the photooxygenation of aryl cyclopropanes upon irradiation with visible light. The effectiveness of this photocatalyst enables the synthesis of a range of five-membered endoperoxides in excellent yield with quite low (0.5 mol %) catalyst loadings even when standard household light sources are utilized.

Simultaneous Capture of Two Distinct Radical Ion Intermediates Generated from the EDA Complexes of Three-Membered Compounds with TCNE by Photoexcitation and in the Dark

Irradiation of the electron donor-acceptor (EDA) complexes of 2,2-diaryl-1-methylenecyclopropanes, 1,1,2,2-tetraarylcyclopropanes, 2,3-diaryloxiranes, or 2,3-diarylaziridines with tetracyanoethylene (TCNE) under aerated conditions involved oxygenation and

PHOTO-OXYGENATION OF 1,2-DIARYLCYCLOPROPANES VIA ELECTRON TRANSFER

The photo-oxygenation of 1,2-diarylcyclopropanes bearing electron-donating substituents in the presence of 9,10-dicyanoanthracene (DCA) in acetonitrile affords trans- and cis-3,5-diaryl-1,2-dioxolanes in excellent yields.The DCA-sensitized photo-oxygenation of less electron-rich 1,2-diarylcyclopropanes gives various oxidation products in low yields.These photoreactions are greatly accelerated by the addition of certain aromatic hydrocarbons and metal salts, and are completely quenched by the addition of triethylamine and 1,4-diazabicyclooctane.No photo-oxygenation takes place in non-polar solvents.The electron transfer mechanism is proposed for the photo-oxygenations, in which the cation radicals of 1,2-diarylcyclopropanes are involved as chain carriers.

PHOTOOXYGENATION OF 1,2-DIARYLCYCLOPROPANES: FORMATION OF 3,5-DIARYL-1,2-DIOXOLANES VIA PHOTOINDUCED ELECTRON TRANSFER

The photooxygenation of electron-rich 1,2-diarylcyclopropanes such as 1,2-bis(4-methoxyphenyl)cyclopropane and 1-(4-methoxyphenyl)-2-phenyl-cyclopropane in the presence of 9,10-dicyanoanthracene (DCA) as a sensitizer in acetonitrile affords trans- and cis-3,5-diaryl-1,2-dioxolanes in high yields.This photooxygenation is initiated by the electron transfer from 1,2-diarylcyclopropanes to the excited singlet DCA, involving the cation radical of cyclopropanes as a key intermediate.