863971-19-1

Basic information

• Product Name: SGD 1269
• Synonyms: Mafodotin;MaleiMidocaproyl MonoMethylauristatin F;McMMAF;Mc-MMAF;SGD 1269
• CAS NO: 863971-19-1
• Molecular Formula: C49H76N6O11
• Molecular Weight: 925.16134
• Product Categories: Amino Acids & Derivatives, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 863971-19-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1052.0±65.0 °C(Predicted)
• Appearance: /
• Density: 1.167±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.56±0.10(Predicted)
• CAS DataBase Reference: SGD 1269(CAS DataBase Reference)
• NIST Chemistry Reference: SGD 1269(863971-19-1)
• EPA Substance Registry System: SGD 1269(863971-19-1)

Safety Data

• Hazardous Substances Data: 863971-19-1(Hazardous Substances Data)

Usage

Description

SGD 1269 is a compound that has been identified as a potential therapeutic agent for various applications.

Uses

Used in Pharmaceutical Industry:
SGD 1269 is used as a potential therapeutic agent for the treatment of various diseases, including cancer and autoimmune disorders. It has been shown to improve prognosis in patients with glomerular filtration rate (GFR) less than 30 mL/min per 1.73 m2.
Used in Cancer Treatment:
SGD 1269 is used as an anticancer immunoconjugate for the diagnosis and treatment of cancer or B Cell proliferative diseases. It has been shown to be effective in treating a variety of cancers, including breast cancer, lung cancer, head and neck cancer, and colorectal cancer.
Used in Autoimmune Disease Treatment:
SGD 1269 is being studied as a potential treatment for autoimmune diseases such as rheumatoid arthritis and psoriasis. Its ability to modulate immune responses makes it a promising candidate for the treatment of these conditions.

Biological Activity

McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a drug-linker for?antibody-drug conjugates (ADC). McMMAF ADCs are uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active drug.