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BZ-NLE-LYS-ARG-ARG-AMC is a fluorogenic peptide substrate that is specifically designed for the detection and quantification of protease activity. It is composed of a series of amino acids, including benzyloxycarbonyl (BZ), norleucine (NLE), lysine (LYS), arginine (ARG), and 7-amino-4-methylcoumarin (AMC). Upon enzymatic cleavage by specific proteases, the AMC molecule is released, and its fluorescence can be measured to determine the activity of the protease.

863975-32-0

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863975-32-0 Usage

Uses

Used in Protease Activity Assays:
BZ-NLE-LYS-ARG-ARG-AMC is used as a substrate in protease activity assays to measure the activity of specific proteases. The release of AMC upon enzymatic cleavage allows for the quantification of protease activity, which can be useful in various research and diagnostic applications.
Used in Viral Protease Detection:
BZ-NLE-LYS-ARG-ARG-AMC is particularly useful in detecting the activity of viral proteases, such as the yellow fever virus (YFV) non-structural 3 (NS3) and dengue virus (DV) NS2B/3 serine proteases. The fluorescence emitted by AMC upon cleavage can be used to monitor the activity of these viral proteases, aiding in the study of viral replication and the development of antiviral therapies.
Used in Drug Discovery and Development:
In the pharmaceutical industry, BZ-NLE-LYS-ARG-ARG-AMC can be employed as a tool in drug discovery and development. By monitoring the activity of specific proteases, researchers can evaluate the efficacy of potential drug candidates that target these enzymes, leading to the development of new treatments for various diseases.
Used in Diagnostic Applications:
BZ-NLE-LYS-ARG-ARG-AMC can also be utilized in diagnostic applications, where the detection and quantification of specific protease activity can provide valuable information about a patient's health. For example, abnormal protease activity may be indicative of certain diseases or conditions, and the use of this substrate can aid in their diagnosis and monitoring.

Check Digit Verification of cas no

The CAS Registry Mumber 863975-32-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,3,9,7 and 5 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 863975-32:
(8*8)+(7*6)+(6*3)+(5*9)+(4*7)+(3*5)+(2*3)+(1*2)=220
220 % 10 = 0
So 863975-32-0 is a valid CAS Registry Number.

863975-32-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Bz-Nle-Lys-Arg-Arg-AMC

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:863975-32-0 SDS

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