863977-37-1

Basic information

• Product Name: (4-{[(benzyl-methyl-carbamoyl)-methyl]-sulfamoyl}-phenoxy)-acetic acid tert-butyl ester
• CAS NO: 863977-37-1
• Molecular Weight: 448.54
• Mol File: 863977-37-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-{[(benzyl-methyl-carbamoyl)-methyl]-sulfamoyl}-phenoxy)-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (4-{[(benzyl-methyl-carbamoyl)-methyl]-sulfamoyl}-phenoxy)-acetic acid tert-butyl ester(863977-37-1)
• EPA Substance Registry System: (4-{[(benzyl-methyl-carbamoyl)-methyl]-sulfamoyl}-phenoxy)-acetic acid tert-butyl ester(863977-37-1)

Safety Data

• Hazardous Substances Data: 863977-37-1(Hazardous Substances Data)

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 179874-14-7 tert-butyl (2-(benzyl(methyl)amino)-2-oxoethyl)carbamate 
• 82155-38-2 N-methyl-N-benzylglycinamide 

Relevant articles and documents

Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors

A series of novel sulfonamides containing a single difluoromethylene- phosphonate group were discovered to be potent inhibitors of protein tyrosine phosphatase 1B. Structure-activity relationships around the scaffold were investigated, leading to the identification of compounds with IC50 or Ki values in the low nanomolar range. These sulfonamide-based inhibitors exhibit 100 and 30 times higher inhibitory activity than the corresponding tertiary amines and carboxamides, respectively.