863981-35-5

Basic information

• Product Name: 2',3',5'-tri-O-benzoyl-4,5,6,7-tetrabromo-1-β-D-ribofuranosyl-1H-benzotriazole
• Synonyms: 2',3',5'-tri-O-benzoyl-4,5,6,7-tetrabromo-1-β-D-ribofuranosyl-1H-benzotriazole
• CAS NO: 863981-35-5
• Molecular Weight: 879.151
• Mol File: 863981-35-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2',3',5'-tri-O-benzoyl-4,5,6,7-tetrabromo-1-β-D-ribofuranosyl-1H-benzotriazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2',3',5'-tri-O-benzoyl-4,5,6,7-tetrabromo-1-β-D-ribofuranosyl-1H-benzotriazole(863981-35-5)
• EPA Substance Registry System: 2',3',5'-tri-O-benzoyl-4,5,6,7-tetrabromo-1-β-D-ribofuranosyl-1H-benzotriazole(863981-35-5)

Safety Data

• Hazardous Substances Data: 863981-35-5(Hazardous Substances Data)

Upstream product

• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 17374-26-4 4,5,6,7-tetrabromobenzotriazole 

Relevant articles and documents

Inhibitors of the NTPase/helicases of hepatitis C and related Flaviviridae viruses.

Abstract: In the search for inhibitors of the non-structural protein 3 (NS3)-associated NTPase/helicase activities of the hepatitis C virus (HCV), and of the related West Nile Virus (WNV), and Japanese Encephalitis Virus (JEV), random screening of a broad range of unrelated low-molecular weight compounds revealed that 4,5,6,7-tetrabromo-1H-benzotriazole (TBBT) is a good inhibitor of the helicase activity of HCV and WNV NTPase/helicases (IC50 >> 20 mM and 1.7 mM with a DNA substrate), but a very weak inhibitor of the JEV enzyme (IC50 >> 200 mM). The synthesis of new TBBT derivatives was undertaken and their inhibitory activities against HCV, WNV, and JEV NTPase/helicases and cytotoxicities were examined. The N-alkyl derivatives showed good activity and lower cytotoxicity than TBBT.