86402-30-4Relevant articles and documents
Access to pyridines via cascade nucleophilic addition reaction of 1,2,3-triazines with activated ketones or acetonitriles
Zhang, Yuan,Luo, Han,Lu, Qixing,An, Qiaoyu,Li, You,Li, Shanshan,Tang, Zongyuan,Li, Baosheng
supporting information, p. 393 - 396 (2020/05/18)
We studied the cascade nucleophilic addition reactions of 1,2,3-triazines with activated acetonitriles or ketones, which were used to construct highly substituted pyridines that are not easily accessed by conventional methods. The strategy addressed some structural diversity issues currently facing medicinal chemistry, and the resulting pyridines could be used as convenient precursors for the synthesis of related pharmaceuticals. In particular, our method was applied to the syntheses of the marketed drug etoricoxib and several biologically important molecules in a few steps.
1,2,3-Triazines,III. - Synthesis of N-Aminopyrazoles and their Oxidation to 1,2,3-Triazines. Molecular Structure of 1,2,3-Triazine
Neunhoeffer, Hans,Clausen, Monika,Voetter, Hans-Dieter,Ohl, Harald,Krueger, Carl,Angermund, K.
, p. 1732 - 1751 (2007/10/02)
Oxidation of the N-aminopyrazoles 4a-i affords the 1,2,3-triazines 5a-i.Spectra and reactions - such as oxidation, reduction, and cycloaddition reactions - of some 1,2,3-triazines 5 are described.The X-ray analysis of 5a is presented.
