864055-80-1Relevant academic research and scientific papers
5(Z)-Benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators
Ardecky, Robert J.,Hudson, Andrew R.,Phillips, Dean P.,Tyhonas, John S.,Deckhut, Charlotte,Lau, Thomas L.,Li, Yongkai,Martinborough, Esther A.,Roach, Steven L.,Higuchi, Robert I.,Lopez, Francisco J.,Marschke, Keith B.,Miner, Jeffrey N.,Karanewsky, Donald S.,Negro-Vilar, Andres,Zhi, Lin
, p. 4158 - 4162 (2007)
A series of 5-benzylidene-1,2-dihydro-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes was synthesized and profiled for their ability to act as selective glucocorticoid receptor modulators (SGRMs). The synthesis and structure-activity relationships for this serie
GLUCOCORTICOID RECEPTOR MODULATOR COMPOUNDS AND METHODS- UTILITY
-
Page/Page column 202, (2008/06/13)
Provided herein are compounds of Formula (I) and pharmaceutically acceptable derivatives thereof. Certain of such compounds are selective glucocorticoid receptor modulators and/or selective glucocorticoid binding agents. Also provided are methods of makin
