86407-93-4

Basic information

• Product Name: 2-(1,3-benzothiazol-2-ylsulfanyl)-N-{4-nitrophenyl}acetamide
• Synonyms: 2-(1,3-benzothiazol-2-ylsulfanyl)-N-{4-nitrophenyl}acetamide
• CAS NO: 86407-93-4
• Molecular Formula: C₁₅H₁₁N₃O₃S₂
• Molecular Weight: 345.39614
• Mol File: 86407-93-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(1,3-benzothiazol-2-ylsulfanyl)-N-{4-nitrophenyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1,3-benzothiazol-2-ylsulfanyl)-N-{4-nitrophenyl}acetamide(86407-93-4)
• EPA Substance Registry System: 2-(1,3-benzothiazol-2-ylsulfanyl)-N-{4-nitrophenyl}acetamide(86407-93-4)

Safety Data

• Hazardous Substances Data: 86407-93-4(Hazardous Substances Data)

Upstream product

• 6295-57-4 2-benzthiazole thioacetic acid 
• 100-01-6 4-nitro-aniline 
• 149-30-4 2-Mercaptobenzothiazole 
• 17329-87-2 2-chloro-N-(4-nitro-phenyl)-acetamide 

Relevant articles and documents

Sulfur rich 2-mercaptobenzothiazole and 1,2,3-triazole conjugates as novel antitubercular agents

A series of benzfused heterocyclic derivatives such as amide conjugates of 2-(benzo[d]thiazol-2-ylthio)acetic acid with aromatic/aliphatic/cyclic secondary amines (5a-5o & 8a-8m); 1,2,3-triazole conjugates of 2- mercaptobenzothiazoles and amide conjugates of indole-3-glyoxalic acid with cyclic secondary amines (14a-14g) have been synthesized and were screened for their antitubercular activity against Mycobacterium tuberculosis H37Rv strain by broth microdilution assay method. Compounds 8b, 8f, 8g and 8l inhibited the growth of the H37Rv strain at concentrations of 8 μg/mL. These compounds (8b, 8f, 8g and 8l) have been further identified as bactericidal and are completely killing the microbes at 32-64 μg/mL concentrations. Molecular docking studies of the active compounds reveal that these compounds are targeting DprE1 and may act as DprE1 inhibitors.