86408-72-2

Basic information

• Product Name: Ecabet sodium
• Synonyms: ta-2711;ECABET SODIUM;(1r-(1-alpha,4a-beta,10a-alpha))-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid sodium salt;ECABET SODIUM,99+%;Ecabetsodiumsalt;1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, monosodium salt, (1R,4aS,10aR)-;1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, monosodium salt, [1R-(1α,4aβ,10aα)]-;Gastrom
• CAS NO: 86408-72-2
• Molecular Formula: C₂₀H₂₇O₅S*Na
• Molecular Weight: 402.48
• EINECS: 1312995-182-4
• Product Categories: Inhibitors
• Mol File: 86408-72-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300°
• Appearance: /
• Density: 1.241 g/cm^3/sup>
• Refractive Index: 1.562
• CAS DataBase Reference: Ecabet sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Ecabet sodium(86408-72-2)
• EPA Substance Registry System: Ecabet sodium(86408-72-2)

Safety Data

• Hazardous Substances Data: 86408-72-2(Hazardous Substances Data)

Usage

Description

Ecabet sodium is a new antiulcer agent launched in Japan for the treatment of gastric ulcer. It has both mucosal-protective and tissue-repairing properties. In rats, it effectively prevents gastrointestinal lesion formation induced experimentally by EtOH, HCl, NaOH, and boiling water. The mechanism of action has been suggested to involve inhibition of pepsin activity in gastric juice by precipitating pepsin in the form of a complex and inactivating pepsinogen.

Brand name

Gastrom

InChI:InChI=1/C20H28O5S/c1-12(2)15-9-13-5-6-14-11-19(3,18(21)22)7-8-20(14,4)16(13)10-17(15)26(23,24)25/h9-10,12,14H,5-8,11H2,1-4H3,(H,21,22)(H,23,24,25)/t14-,19+,20-/m0/s1

Upstream product

• 33159-27-2 12-sulfodehydroabietic acid 
• 86408-71-1 12-sulfodehydroabietic acid disodium salt 

Downstream Products

• 86409-23-6 (1R,4aS,10aR)-7-Isopropyl-1,4a-dimethyl-6-sulfo-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid; compound with 1-(2-dimethylamino-ethyl)-4-phenyl-pyrrolidin-2-one 
• 86408-75-5 12-sulfodehydroabietic acid calcium salt 
• 97363-82-1 (1R,4aS,10aR)-6-(4-Carboxy-phenylsulfamoyl)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid 
• 97363-81-0 (1R,4aS,10aR)-6-(1-Carboxy-2-phenyl-ethylsulfamoyl)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid 

Relevant articles and documents

One method for preparing card time of special sodium

The invention discloses a method for preparing ecabet sodium. The method disclosed by the invention is characterized by comprising the following steps of carrying out sulfonation reaction on dehydroabietic acid (formula III) as a starting material and fuming sulfuric acid to obtain 12-sulfonic dehydroabietic acid (formula II) and enabling the compound shown as the formula II and a sodium-forming agent to form a sodium salt in a solvent system at least containing water to obtain ecabet sodium. By virtue of the method disclosed by the invention, the deficiencies of the prior art are overcome and the method has the advantage of high sulfonation yield and high selectivity in sodium salt forming, simple operation, safety and environment friendliness and is suitable for industrial production.