864146-95-2

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-Acetyl-piperazin-1-yl)-2-fluoroaniline is used as a building block for the synthesis of various pharmaceutical drugs and agrochemicals. Its potential antineoplastic and anticonvulsant properties make it a promising candidate for the development of new therapeutic agents.
Used in Enzyme Inhibition:
4-(4-Acetyl-piperazin-1-yl)-2-fluoroaniline is used as a potential inhibitor of the enzyme caspase-3, which plays a key role in apoptosis. By inhibiting caspase-3, FIASP may have potential applications in the treatment of diseases associated with abnormal cell death.
Used in Research and Development:
4-(4-Acetyl-piperazin-1-yl)-2-fluoroaniline is used in research and development for the study of its potential antineoplastic and anticonvulsant properties. Further research is needed to fully understand its mechanism of action and potential therapeutic applications.

InChI:InChI=1/C12H16FN3O/c1-9(17)15-4-6-16(7-5-15)10-2-3-12(14)11(13)8-10/h2-3,8H,4-7,14H2,1H3

Upstream product

• 13889-98-0 N-acetylpiperidine 
• 369-34-6 3,4-difluoronitrobenzene 
• 330636-42-5 1-[4-(2-fluoro-4-nitro-phenyl)-piperazin-1-yl]-ethanone 

Relevant academic research and scientific papers

Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M

The covalent binding nature of irreversible kinase inhibitors potentially increases the severity of “off-target” toxicity. Based on our continual strategy of chemically tuning the Michael addition acceptors, herein, we further explore the relationship amo

Design and synthesis of novel 5-acetylthiomethyl oxazolidinone analogs

The oxazolidinone class of antimicrobial agents represents a promising advance in the fight against resistant Gram-positive bacterial infections. To improve antibacterial activity and expand the spectrum of activity including Gram-negative bacteria, a series of novel 5-acetylthiomethyl oxazolidinone analogs were designed and synthesized based on the structure-activity relationship studies. The structures of the target compounds and main intermediates were confirmed by 1H NMR, 13C NMR, infrared (IR), mass spectra (MS), and elemental analysis.

N-(3,4-disubstituted phenyl) salicylamide derivatives

A compound represented by the following formula (I) or a salt thereof: wherein R1, R2, R3 and R4 represent hydrogen atom, a halogen atom, cyano group, nitro group, a C1-4 alkyl group, a halogenated C

NOVEL TRIAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS AND THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The present invention relates to novel triazole compounds of formula (I), where all symbols are as defined in the detailed description; their pharmaceutically acceptable salts their stereosiomers thereof, their prodrugs, their rotamers, their pharmaceutical compositions containing them. The present invention also relates to a process for the preparation of the above said novel compounds.