864148-47-0Relevant academic research and scientific papers
Regio- and Enantioselective Copper-Catalyzed 1,4-Conjugate Addition of Trimethylaluminium to Linear α,β,γ,δ-Unsaturated Alkyl Ketones
Wu, Xiaoting,Xie, Fang,Ling, Zheng,Tang, Liang,Zhang, Wanbin
supporting information, p. 2510 - 2518 (2016/08/16)
A regio- and enantioselective copper-catalyzed 1,4-conjugate addition of trimethylaluminium to linear δ-aryl-substituted α,β,γ,δ-unsaturated alkyl ketones was developed. A series of γ,δ-unsaturated alkyl ketones were obtained in good yields with high regio- and enantioselectivity (up to 88% ee and 96:4 dr). Expansion of the reaction scope to substrates containing aromatic heterocycles also afforded good yields and enantioselectivities (up to 91% ee) with very high regioselectivities, exclusively providing the single 1,4-products. (Figure presented.).
Highly selective 1,6-addition of aryl boronic acids to α,β, γ,δ-unsaturated carbonyl compounds catalyzed by an indium complex
Nishimura, Takahiro,Yasuhara, Yuichi,Hayashi, Tamio
, p. 5164 - 5166 (2007/10/03)
(Chemical Equation Presented) Perfect control: The catalytic 1,6-addition of aryl boronic acids to electron-deficient dienes was realized by use of an iridium catalyst (see scheme). High yields of the corresponding δ-arylated carbonyl compounds were obtai
Rhodium-catalyzed asymmetric 1,6-addition of aryl zinc reagents to dienones
Hayashi, Tamio,Yamamoto, Shohei,Tokunaga, Norihito
, p. 4224 - 4227 (2007/10/03)
(Chemical Equation Presented) A highly enantioselective methodology allows the preparation of α,β-unsaturated ketones that contain a new stereogenic center at the C5 position. This approach is realized through the title reaction in the presence of chlorotrimethylsilane as a Lewis acid and a rhodium/(S)-binap complex as the catalyst followed by acidic hydrolysis (see scheme). binap = 2,2′-bis(diphenylphosphanyl)-1,1′-binaphthyl.
