864148-88-9Relevant articles and documents
Cinchona alkaloid catalyzed enantioselective chlorination of 3-aryloxindoles
Zhao, Mei-Xin,Zhang, Zhi-Wang,Chen, Ming-Xiao,Tang, Wen-Hao,Shi, Min
, p. 3001 - 3008 (2011)
O-Benzoylquinidine is an effective organocatalyst for the asymmetric chlorination of 3-aryloxindoles by using easily available N-chlorosuccinimide (NCS as chlorine source to give the corresponding 3-aryl-3-chlorooxindoles in excellent yields and up to 93% enantiomeric excess. We have developed a highly effective asymmetric α-chlorination reaction of oxindoles by using an inexpensive cinchona alkaloid as the organocatalyst and N-chlorosuccinimide (NCS as the chlorination reagent under mild conditions, providing the corresponding 3-aryl-3-chlorooxindoles in excellent yields and up to 93% ee.
Chiral calcium VAPOL phosphate mediated asymmetric chlorination and Michael reactions of 3-substituted oxindoles
Zheng, Wenhua,Zhang, Zuhui,Kaplan, Matthew J.,Antilla, Jon C.
scheme or table, p. 3339 - 3341 (2011/05/04)
We disclose a novel high yielding and highly enantioselective chiral calcium VAPOL phosphate-catalyzed chlorination of 3-substituted oxindoles with N-chlorosuccinimide (NCS). The reaction conditions are also shown to be effective for the catalytic enantio
Axially chiral BINIM and Ni(II)-catalyzed asymmetric chlorination of 3-substituted oxindoles
Wang, De,Jiang, Jia-Jun,Zhang, Rui,Shi, Min
scheme or table, p. 1133 - 1141 (2011/10/07)
Axially chiral BINIM-Ni(II) complexes are effective catalysts in the asymmetric chlorination of 3-substituted oxindoles and give the corresponding chlorinated adducts in good yields and up to 88% ee.
