864238-53-9

Upstream product

• 864238-49-3 (4S)-isobutyl-(5S)-(2-methoxycarbonyl-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 864238-48-2 (4S,5S)-isobutyl-5-methoxycarbonylethynyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 864238-52-8 (4S)-isobutyl-(5S)-((2R)-methoxycarbonyl-cyclopentyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 864238-51-7 (4S)-isobutyl-(5S)-((2R)-methoxycarbonyl-4-oxo-cyclopentyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 728947-30-6 (5S)-tert-butoxycarbonylamino-(4S,R)-hydroxy-7-methyl-oct-2-ynoic acid methyl ester 
• 864239-02-1 C₂₈H₄₃N₃O₇S 
• 864239-04-3 H-Ala-Glu(OBn)-Phe-OBn 
• 137822-48-1 (4S,5S)-5-((1R,2R)-2-Carboxy-cyclopentyl)-4-isobutyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 58521-45-2 tert-butoxycarbonyl-L-leucinal 
• 864238-50-6 (4S)-isobutyl-(5S)-((2R)-methoxycarbonyl-4-methylenecyclopentyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Downstream Products

• 864238-59-5 4-(1-benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-4-{2-[(2-{2-[2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-(trityl-carbamoyl)-propionylamino]-1-hydroxy-4-methyl-pentyl}-cyclopentanecarbonyl)-amino]-propionylamino}-butyric acid benzyl ester 
• 864238-56-2 4-(1-benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)-4-{2-[(2-{2-[2-tert-butoxycarbonylamino-3-(trityl-carbamoyl)-propionylamino]-1-hydroxy-4-methyl-pentyl}-cyclopentanecarbonyl)-amino]-propionylamino}-butyric acid benzyl ester 

Relevant academic research and scientific papers

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

Molecular modeling based on the X-ray crystal structure of the Tang-Ghosh heptapeptide inhibitor 1 (OM99-2) of BACE led to the design and synthesis of a series of constrained P1′ analogues. A cyclopentane ring was incorporated in 1 spanning the