864239-10-1

Upstream product

• 169057-41-4 (1S,2S,3R)-(2,5-dihydroxy-1-isobutyl-4-methyl-pentyl)carbamic acid tert-butyl ester 
• 169057-47-0 (3R,5S,1'S)-5-[1'-[(tert-butyloxycarbonyl)amino]-3'-methylbutyl]-3-methyldihydrofuran-2(3H)-one 
• 13734-41-3 t-Boc-L-valine 
• 864239-09-8 (S)-2-{(2R,4S,5S)-4-Benzyloxy-5-[(S)-2-tert-butoxycarbonylamino-3-(trityl-carbamoyl)-propionylamino]-2,7-dimethyl-octanoylamino}-propionic acid benzyl ester 
• 864239-08-7 (S)-2-((2R,4S,5S)-4-Benzyloxy-5-tert-butoxycarbonylamino-2,7-dimethyl-octanoylamino)-propionic acid benzyl ester 
• 864239-06-5 2,2-dimethylpropionic acid (4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctyl ester 
• 864239-07-6 (4S)-benzyloxy-(5S)-tert-butoxycarbonylamino-(2R),7-dimethyloctanoic acid 
• 864239-05-4 2,2-dimethylpropionic acid (5S)-tert-butoxycarbonylamino-(4S)-hydroxy-(2R),7-dimethyloctyl ester 

Downstream Products

• 864239-11-2 (S)-4-{(S)-1-[(S)-1-[(1S,2S,4R)-2-Benzyloxy-4-((S)-1-benzyloxycarbonyl-ethylcarbamoyl)-1-isobutyl-pentylcarbamoyl]-2-(trityl-carbamoyl)-ethylcarbamoyl]-2-methyl-propylcarbamoyl}-4-benzyloxycarbonylamino-butyric acid benzyl ester 

Relevant academic research and scientific papers

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

Molecular modeling based on the X-ray crystal structure of the Tang-Ghosh heptapeptide inhibitor 1 (OM99-2) of BACE led to the design and synthesis of a series of constrained P1′ analogues. A cyclopentane ring was incorporated in 1 spanning the