86425-58-3

Basic information

• Product Name: N-cyclohexyl-3,4,5-trimethoxybenzamide
• Synonyms: N-cyclohexyl-3,4,5-trimethoxybenzamide
• CAS NO: 86425-58-3
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.35812
• Mol File: 86425-58-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 180 °C
• Boiling Point: 393.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 13.91±0.20(Predicted)
• CAS DataBase Reference: N-cyclohexyl-3,4,5-trimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-3,4,5-trimethoxybenzamide(86425-58-3)
• EPA Substance Registry System: N-cyclohexyl-3,4,5-trimethoxybenzamide(86425-58-3)

Safety Data

• Hazardous Substances Data: 86425-58-3(Hazardous Substances Data)

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 108-91-8 cyclohexylamine 

Relevant articles and documents

In situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes

An environmentally friendly synthetic route by the application of CO2 to synthesize amides via in situ protection and deprotection of amines for iron catalyzed oxidative amidation of aldehydes was developed. Various secondary and tertiary amides have been synthesized in moderate to good yields under mild and neutral reaction conditions. The use of amine hydrochloride salts and hence base for neutralization step is totally avoided in this protocol.

Amides and formamidines with antinociceptive activity (note II)

Forty amides, formamidines and trifluoromethylsulfonylamides bearing on the nitrogen a cyclohexyl residue, eventually 2-substituted, were prepared and tested for analgesic activity against a chemical stimulus. Good activity was exhibited by amides 9, 11 and 28, by formamidine 34, as well as by triflylamide 40. Eleven additional compounds exhibited a moderate activity.