86426-17-7

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Basic information

Product Name: Mildronate dihydrate
Synonyms: 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate;Mildronate dihydrate;Mildronatedehydrate;Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt;Meldonium;Mildronate dihydrate, >=99%;Mildronate (hydrate);3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate dihydrate
CAS NO:86426-17-7
Molecular Formula: C6H14N2O2.2H2O
Molecular Weight: 182.218
EINECS: 1592732-453-0
Product Categories: Cardiovascular APIs;Inhibitors
Mol File: 86426-17-7.mol
Article Data: 0

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: white to off-white/
Density: N/A
Refractive Index: N/A
Storage Temp.: 2-8°C
Solubility: H2O: >40mg/mL
CAS DataBase Reference: Mildronate dihydrate(CAS DataBase Reference)
NIST Chemistry Reference: Mildronate dihydrate(86426-17-7)
EPA Substance Registry System: Mildronate dihydrate(86426-17-7)

Safety Data

Hazard Codes: Xi
Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 86426-17-7(Hazardous Substances Data)

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86426-17-7 Usage

Description

Mildronate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively.

Uses

Meldonium dihydrate has been used as an anti-ischemic agent to evaluate its protective effects on Ischemia-reperfusion (I/R) in chick embryos.

Biochem/physiol Actions

Meldonium is an Inhibitor of γ-butyrobetaine hydroxylase (BBOX) a key enzyme in the synthesis of carnitine.

Check Digit Verification of cas no

The CAS Registry Mumber 86426-17-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,2 and 6 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 86426-17:
(7*8)+(6*6)+(5*4)+(4*2)+(3*6)+(2*1)+(1*7)=147
147 % 10 = 7
So 86426-17-7 is a valid CAS Registry Number.

86426-17-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name	Mildronate dihydrate

1.2 Other means of identification

Product number	-
Other names	3-(2,2,2-Trimethylhydrazinium)propionate dihydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:86426-17-7 SDS

CAS

86426-17-7

86426-17-7

Basic information

Chemical Properties

Safety Data

86426-17-7 Suppliers

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86426-17-7 Usage

Description

Uses

Biochem/physiol Actions

Check Digit Verification of cas no

86426-17-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

1.Identification

1.1 GHS Product identifier

1.2 Other means of identification

1.3 Recommended use of the chemical and restrictions on use

1.4 Supplier's details

1.5 Emergency phone number

86426-17-7Upstream product

86426-17-7Downstream Products