864266-60-4 Usage
Description
[4-(CYCLOPENTYLOXY)PHENYL]METHANAMINE, with the molecular formula C11H15NO, is an amine derivative featuring a phenyl ring substituted with a cyclopentyloxy group and connected to a methanamine group. This chemical compound is recognized for its diverse reactivity and potential as a building block in organic chemistry, making it a valuable component in scientific and industrial applications.
Uses
Used in Pharmaceutical Synthesis:
[4-(CYCLOPENTYLOXY)PHENYL]METHANAMINE is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Organic Chemistry:
In the field of organic chemistry, [4-(CYCLOPENTYLOXY)PHENYL]METHANAMINE serves as a versatile building block. It is utilized in the synthesis of other organic compounds, showcasing its diverse reactivity and structural properties.
Used as a Research Tool:
[4-(CYCLOPENTYLOXY)PHENYL]METHANAMINE is also employed as a research tool in the development of new chemical reactions. Its unique structure and properties make it an essential component in studying molecular interactions and advancing the understanding of chemical processes.
Used in Chemical Reaction Studies:
[4-(CYCLOPENTYLOXY)PHENYL]METHANAMINE is used as a research tool for studying the mechanisms and outcomes of various chemical reactions. Its application in this field aids in the discovery of novel reaction pathways and the optimization of existing ones.
Check Digit Verification of cas no
The CAS Registry Mumber 864266-60-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,4,2,6 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 864266-60:
(8*8)+(7*6)+(6*4)+(5*2)+(4*6)+(3*6)+(2*6)+(1*0)=194
194 % 10 = 4
So 864266-60-4 is a valid CAS Registry Number.
864266-60-4Relevant articles and documents
Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction
Neochoritis, Constantinos G.,Atmaj, Jack,Twarda-Clapa, Aleksandra,Surmiak, Ewa,Skalniak, Lukasz,K?hler, Lisa-Maria,Muszak, Damian,Kurpiewska, Katarzyna,Kalinowska-T?u?cik, Justyna,Beck, Barbara,Holak,D?mling, Alexander
supporting information, (2019/08/20)
Intrinsically disordered proteins are an emerging class of proteins without a folded structure and currently disorder-based drug targeting remains a challenge. p53 is the principal regulator of cell division and growth whereas MDM2 consists its main negative regulator. The MDM2-p53 recognition is a dynamic and multistage process that amongst other, employs the dissociation of a transient α-helical N-terminal ‘‘lid’’ segment of MDM2 from the proximity of the p53-complementary interface. Several small molecule inhibitors have been reported to inhibit the formation of the p53-MDM2 complex with the vast majority mimicking the p53 residues Phe19, Trp23 and Leu26. Recently, we have described the transit from the 3-point to 4-point pharmacophore model stabilizing this intrinsically disordered N-terminus by increasing the binding affinity by a factor of 3. Therefore, we performed a thorough SAR analysis, including chiral separation of key compound which was evaluated by FP and 2D NMR. Finally, p53-specific anti-cancer activity towards p53-wild-type cancer cells was observed for several representative compounds.
