864268-99-5Relevant academic research and scientific papers
Model studies in the lepadin series: Synthesis of enantiopure decahydroquinolines by aminocyclization of 2-(3-aminoalkyl)cyclohexenones
Mena, Marisa,Bonjoch, Josep
, p. 8264 - 8270 (2007/10/03)
Syntheses of enantiopure 3-acetoxy-2-methyldecahydroquinolines are accomplished by coupling cyclohexenyllithium 3 with α-amino epoxides and an aminocyclization of 2-(3-aminoalkyl)cyclohexenones (i.e., 5 and 9) as the key steps. The procedure allows the incorporation of alkyl substituents at C(5) to give enantiopure 2,3,5-trisubstitued decahydroquinolines.
